Charles A Dinarello Selected Research

Interleukins

5/2022	Circulating interleukin-37 declines with aging in healthy humans: relations to healthspan indicators and IL37 gene SNPs.
1/2022	IL-37 regulates allergic inflammation by counterbalancing pro-inflammatory IL-1 and IL-33.
1/2021	Interleukins in cancer: from biology to therapy.
1/2021	Reduced concentrations of the B cell cytokine interleukin 38 are associated with cardiovascular disease risk in overweight subjects.
1/2021	IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8.
1/2021	IL-18 and infections: Is there a role for targeted therapies?
1/2021	Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses.
12/2020	The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease.
5/2020	Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial.
1/2020	Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout.

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Charles A Dinarello Research Topics

Disease

148	Inflammation (Inflammations) 05/2022 - 01/2002
39	Neoplasms (Cancer) 05/2022 - 01/2002
36	Infections 01/2021 - 01/2002
20	Rheumatoid Arthritis 01/2020 - 03/2003
20	Autoimmune Diseases (Autoimmune Disease) 02/2016 - 03/2002
16	Colitis 01/2022 - 04/2006
13	Atherosclerosis 01/2020 - 01/2002
11	Heart Failure 01/2022 - 03/2003
11	Psoriasis (Pustulosis Palmaris et Plantaris) 11/2020 - 06/2003
11	Fever (Fevers) 11/2020 - 03/2002
11	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2018 - 03/2004
9	Arthritis (Polyarthritis) 01/2021 - 09/2006
9	Melanoma (Melanoma, Malignant) 01/2021 - 01/2003
9	Gout 05/2020 - 12/2013
9	Sepsis (Septicemia) 02/2016 - 08/2002
8	Endotoxemia 01/2021 - 01/2002
8	Insulin Resistance 01/2020 - 06/2006
8	Necrosis 01/2017 - 11/2003
8	Disease Progression 04/2015 - 11/2002
8	Acute Kidney Injury (Acute Renal Failure) 12/2013 - 12/2004
7	Myocardial Infarction 01/2022 - 03/2003
7	Fibrosis (Cirrhosis) 01/2022 - 11/2002
7	Obesity 01/2018 - 06/2006
7	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2017 - 01/2005
7	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2017 - 11/2003
7	Crohn Disease (Crohn's Disease) 01/2017 - 04/2002
7	Ischemia 07/2016 - 06/2003
6	Type 2 Diabetes Mellitus (MODY) 12/2019 - 06/2010
6	Fatigue 04/2017 - 05/2011
6	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2016 - 11/2005
6	Hyperglycemia 05/2013 - 06/2006
6	Neoplasm Metastasis (Metastasis) 06/2010 - 01/2003
5	Carcinogenesis 01/2019 - 09/2006
5	Macrophage Activation Syndrome 02/2016 - 11/2005
5	Emphysema 06/2014 - 06/2013
5	Experimental Melanoma 04/2013 - 01/2003
5	Hepatitis 01/2007 - 01/2005
4	Pneumonia (Pneumonitis) 11/2020 - 02/2002
4	Left Ventricular Dysfunction 01/2018 - 01/2012
3	Neuroinflammatory Diseases 01/2022 - 08/2002
3	Asthma (Bronchial Asthma) 01/2022 - 01/2019
3	Weight Loss (Weight Reduction) 01/2022 - 06/2008
3	Cystic Fibrosis (Mucoviscidosis) 01/2022 - 11/2014
3	Metabolic Diseases (Metabolic Disease) 01/2021 - 10/2015
3	Leukemia 01/2021 - 03/2004
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 12/2015
3	Peritonitis 01/2021 - 01/2019

Drug/Important Bio-Agent (IBA)

126	CytokinesIBA 05/2022 - 01/2002
81	Interleukin-1 (Interleukin 1)IBA 01/2022 - 01/2002
53	Interleukin-18 (Interleukin 18)IBA 01/2022 - 03/2002
46	InterleukinsIBA 05/2022 - 02/2002
38	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 01/2022 - 10/2003
32	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2022 - 02/2002
27	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2017 - 04/2002
26	InflammasomesIBA 05/2022 - 02/2010
26	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2002
19	Interleukin-6 (Interleukin 6)IBA 01/2021 - 03/2003
15	Biological ProductsIBA 02/2019 - 01/2002
13	Histone Deacetylase InhibitorsIBA 01/2018 - 03/2004
11	Carrier Proteins (Binding Protein)IBA 06/2015 - 01/2003
10	Interleukin-1beta (Interleukin 1 beta)IBA 01/2022 - 08/2002
9	Interleukin-12 (IL 12)IBA 01/2019 - 04/2002
9	Messenger RNA (mRNA)IBA 01/2019 - 06/2010
8	dapansutrileIBA 01/2022 - 01/2018
8	Interleukin-10 (Interleukin 10)IBA 01/2021 - 10/2003
8	Uric Acid (Urate)IBA 01/2021 - 01/2016
8	Biomarkers (Surrogate Marker)IBA 11/2020 - 11/2005
8	ChemokinesIBA 07/2019 - 07/2002
8	Histone Deacetylases (Histone Deacetylase)IBA 10/2017 - 03/2002
8	LigandsIBA 01/2016 - 07/2002
7	Interferon-gamma (Interferon, gamma)IBA 06/2015 - 04/2004
6	Therapeutic UsesIBA 01/2021 - 12/2016
6	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2016 - 01/2004
5	Interleukin-33IBA 01/2022 - 09/2011
5	C-Reactive ProteinIBA 11/2020 - 03/2003
5	Pharmaceutical PreparationsIBA 09/2020 - 05/2011
5	givinostat hydrochlorideIBA 01/2018 - 01/2005
5	Vorinostat FDA Link 10/2017 - 03/2004
5	Interleukin-1alpha (Interleukin 1 alpha)IBA 01/2017 - 03/2003
5	Peptides (Polypeptides)IBA 01/2017 - 05/2008
5	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2014 - 09/2006
5	matrigelIBA 04/2013 - 03/2003
4	Dextran SulfateIBA 01/2022 - 04/2006
4	LipopolysaccharidesIBA 01/2021 - 03/2002
4	EnzymesIBA 09/2020 - 06/2003
4	Protein Isoforms (Isoforms)IBA 01/2020 - 10/2014
4	Interleukin-8 (Interleukin 8)IBA 01/2020 - 10/2003
4	canakinumab FDA Link 01/2020 - 12/2018
4	AlarminsIBA 01/2019 - 04/2014
4	Insulin (Novolin)FDA Link 01/2018 - 09/2003
4	Caspase 1 (ICE Protease)IBA 01/2016 - 04/2007
4	Serine Proteases (Serine Protease)IBA 01/2015 - 02/2006
4	AntibodiesIBA 04/2014 - 09/2004
4	Streptozocin (Streptozotocin)FDA Link 05/2013 - 11/2006
4	Small Interfering RNA (siRNA)IBA 02/2013 - 02/2008
4	p38 Mitogen-Activated Protein KinasesIBA 05/2009 - 06/2004
4	NF-kappa B (NF-kB)IBA 04/2009 - 06/2004
4	interleukin-18 binding proteinIBA 11/2008 - 11/2002
3	Histones (Histone)IBA 01/2021 - 04/2006

Therapy/Procedure

40	Therapeutics 05/2022 - 01/2002